Pentobarbital will decrease the level or effect of ketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 me... https://moodjhomedia.com/story3173746/dice-buzz-su-pentobarbital-veterinario