Comment: Barbiturates might maximize adverse effects, together with respiratory depression, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates improve metabolism and reduce blood concentrations of TCAs. pentobarbital will decrease the level or effect of buprenorphine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. pentobarb... https://jackn765csh2.mybuzzblog.com/profile