You will find there's release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to reduce afferent agony transmission and create analgesia. For that reason, medication like clonidine that focus on alpha-2 receptors can affect the transmission of soreness. : linked to, https://josephb913dyt2.humor-blog.com/profile