TAK-243 preferentially sure to UBA1 over the linked E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased amounts of ubiquitylated proteins, increased markers of proteotoxic strain and DNA destruction anxiety. In vivo, TAK-243 reduced leukemic load and specific leukemic stem cells without having https://freemani554ewo5.vidublog.com/profile