The identified effect of these PTMs on ATXN2’s purpose and SCA2 pathogenesis remains constrained. In other polyQ illnesses, various studies advised that proteolytic cleavage of polyQ proteins could Participate in a very important purpose in pathogenesis [36, forty five]. Aligned using this type of notion, the presence of an enriched https://chk1-in-491357.designi1.com/50300494/the-5-second-trick-for-ataxin-8-protein